UMEM Educational Pearls

Category: Toxicology

Title: Quinolone Induced Delirium

Keywords: levofloxacin (PubMed Search)

Posted: 1/21/2010 by Fermin Barrueto, MD (Updated: 8/21/2019)
Click here to contact Fermin Barrueto, MD

Quinolone Induced Deliurim

Just to give you another reason NOT to give a quinolone - aside from the C. diff. This adverse effect occurs with quinolones unlike many other antibiotics. It can prolong hospital stay, cause falls and further medical work ups. Some risk factors are:

  • Elderly
  • Renal Insufficiency
  • Benzodiazepine dependence (will actually precipitate withdrawal since quinolones displace the BDZ from the receptor - you have probably done this to a patient if you think about it, that may be why they went crazy)
  • Epilepsy - can cause seizures especially with NSAIDs