Keywords: Epstien Barr Virus, Mononucleosis (PubMed Search)
Epstein-Barr virus (EBV)-associated infectious mononucleosis (IM)
Most commonly presenting clinical findings: fever, fatigue, exudative pharyngitis, lymphadenopathy, and hepatosplenomegaly.
Self-limited illness that lasts an average of 2 - 3 weeks.
Treatment is primarily supportive. Use of ampicillin, amoxicillin, or penicillin during the acute phase not indicated and may result in the development of a morbilliform rash, which studies have suggested may occur in more than 50% of the cases. Antiviral therapy is not recommended. Splenic rupture occurs in about 1 - 2:1000 cases. Therefore, avoidance of activities that increase the risk for injury is recommended until splenomegaly has resolved.
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2012 PREP Self-Assessment, Pediatrics Review and Education Program