Category: Critical Care
Posted: 3/22/2011 by Mike Winters, MBA, MD
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Aspiration Pneumonitis and Pneumonia
Ragavendran K, Nemzek J, Napolitano LM, Knight PR. Aspiration-induced lung injury. Crit Care Med 2011; 39:818-26.
Category: Critical Care
Keywords: pulmonary physiology, critical care, respiratory alkalosis (PubMed Search)
Posted: 3/15/2011 by Haney Mallemat, MD
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Many changes in pulmonary physiology occur during pregnancy. These changes are generally well tolerated but can become problematic when pathologic states arise.
Here are a few examples of the normal changes and potential consequences:
Progesterone increases tidal volume and respiratory rate.
“Normally" a mild respiratory alkalosis pH 7.4-7.47, PaCO2 28-32, and bicarbonate 17-22 (renal compensation).
Low metabolic reserve with systemic illness.
Weight gain, anasarca, and breast size reduces chest wall elasticity.
Potential for restrictive physiology and reduced lung volumes.
Can be challenging to to mechanically ventilate due to decreased compliance and intra-thoracic pressure
Mechanical displacement of abdominal and thoracic contents by growing uterus.
Reduced lung volumes leading to reduced oxygen reserve and decreased apnea time.
Aim higher if placing chest tube (avoid abdominal contents)
Uterine pressure on stomach can increase aspiration risk and pulmonary injury.
Chestnutt, A. Physiology of Normal Pregnancy. Crit Care Clinic 20 (2004) 609-615
Category: Critical Care
Posted: 3/8/2011 by Mike Winters, MBA, MD
(Updated: 7/16/2024)
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The Severely Hypoxemic ED Patient
Patroniti N, Isgro S, Zanella A. Clinical management of severely hypoxemic patients. Curr Opin Crit Care 2011; 17:50-56.
Category: Critical Care
Posted: 2/22/2011 by Mike Winters, MBA, MD
(Updated: 7/16/2024)
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Hemodynamic Monitoring in the Ventilated Patient
Magder S. Hemodynamic monitoring in the mechanically ventilated patient. Curr Opin Crit Care 2011;17:36-42.
Category: Critical Care
Keywords: Pulmonary embolism, PE, echocardiography, ultrasound, hemodynamics, McConnell sign, right ventricle (PubMed Search)
Posted: 2/15/2011 by Haney Mallemat, MD
(Updated: 7/16/2024)
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Casazza F., et al. Regional right ventricular dysfunction in acute pulmonary embolism and right ventricular infarction.Eur J Echocardiography 2005 Jan; 6(1): 11-4.
Category: Critical Care
Posted: 2/8/2011 by Mike Winters, MBA, MD
(Updated: 7/16/2024)
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Acute LV Dysfunction in the Critically Ill
Chockalingam A, Mehra A, Dorairajan S, et al. Acute left ventricular dysfunction in the critically ill. Chest 2010; 138:198-207
Category: Critical Care
Keywords: hemoglobin, anemia, transfusions, hemorrhage, conservative, liberal, hemorrhaging (PubMed Search)
Posted: 2/1/2011 by Haney Mallemat, MD
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The optimal hemoglobin concentration during critical illness is unknown. Although a liberal transfusion strategy (Hb 10-12 g/dL) was once believed to be beneficial for hemodynamics, evidence suggests targeting a conservative strategy (Hb 7-9 g/dL) does not increase mortality, while the unnecessary transfusion of blood products can cause harm (transfusion associated lung injury, infection, etc.) in the non-hemorrhaging patient.
1. Harder, L. Et al. The Optimal Hematocrit. Critical Care Clinics (2010) vol. 26 (2) pp. 335-354
2. Hebert P, Wells G, Blajchman M, et al. A multicenter, randomized, controlled clinical trial of transfusion requirements in critical care. N Engl J Med 1999; 340(6):409–17
Category: Critical Care
Posted: 1/26/2011 by Mike Winters, MBA, MD
(Updated: 7/16/2024)
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Valproic Acid in Status Epilepticus
Pillow MT, Malani N. Best practices for seizure management in the emergency department. ACEP News 2011; 30(1):14-16.
Category: Critical Care
Keywords: Apnea test, brain death, brain stem death, coma, death, cardiopulmonary death (PubMed Search)
Posted: 1/17/2011 by Haney Mallemat, MD
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Brain death is the permanent absence of cerebral and brainstem functions (coma, absent pupillary reflexes, no spontaneous respiration, etc.). Legally, brain death is equivalent to cardiopulmonary death.
If brain death is suspected, confirmation is necessary. The apnea test is most commonly used, evaluating for spontaneous breaths when disconnected from the ventilator. If apnea testing is not possible (e.g., ambiguous clinical exam or cardiopulmonary instability) ancillary testing is needed:
Wijdicks EF, The diagnosis of brain death. N Engl J Med. 2001 Apr 19;344(16):1215-21.
Category: Critical Care
Posted: 1/11/2011 by Mike Winters, MBA, MD
(Updated: 7/16/2024)
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Dexmedetomidine for Sedation in Acute Neurologic Disease
Mirski MA, Lewin JL. Sedation and analgesia in acute neurologic disease. Curr Opin Crit Care 2010; 16:81-91
Category: Critical Care
Keywords: PRES, hypertensive crisis, seizures, visual loss, ecclampsia, hypertensive emergency, cyclopsporine, tacrolimus (PubMed Search)
Posted: 1/4/2011 by Haney Mallemat, MD
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Posterior reversible encephalopathy syndrome (PRES) is a syndrome of visual loss, headache, altered mental status, and seizures, typically with severe hypertension. PRES usually occurs with hypertensive encephalopathy or ecclampsia, although cyclosporin and tacrolimus use have been implicated.
PRES is due to a combination of endothelial damage, impaired auto-regulation and increased cerebral perfusion pressure. Classic CT and MRI findings are parietal-occipital, cerebellar, or brainstem cortical and subcortical edema.
Early recognition and symptomatic treatment is key; IV anti-hypertensives (hypertensive encephalopathy), anti-epileptics (seizures), IV magnesium and emergent delivery (ecclampsia), and discontinuing offending medications (cyclosporin and tacrolimus).
With treatment, partial to complete recovery is normal, although residual neurological and visual deficits may persist.
Pula, J. Posterior reversible encephalopathy syndrome. Current Opinion in Ophthalmology. 2008 vol. 19 (6) pp. 479-84
Category: Critical Care
Posted: 12/28/2010 by Mike Winters, MBA, MD
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Vancomycin Dosing in the Critically Ill Obese Patient
Medico CJ, Walsh P. Pharmacotherapy in the critically ill obese patient. Crit Care Clin 2010; 26:679-88.
Category: Critical Care
Keywords: thrombocytopenia, critically0ill, sepsis, death, mortality, prognosis (PubMed Search)
Posted: 12/21/2010 by Haney Mallemat, MD
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The incidence and prevalence of thrombocytopenia in the ICU is poorly defined however, it has been found to be an independent predictor of death in the critically-ill. Increased mortality does not appear to be related to bleeding complications. On the other hand, survivors of critical illness tend to recover platelet faster as compared to non-survivors.
Thrombocytopenia in the critically-ill is a marker for systemic inflammation/infection although the exact mechanisms are unknown. Common risk factors associated with thrombocytopenia in the ICU population are:
Sepsis
Renal failure
High-illness severity
Organ dysfunction
Bottom line: Thrombocytopenia in the critically-ill is associated with increased mortality.
Hui, P., The Frequency and Clinical Significance of Thrombocytopenia Complicating Critical Illness: A Systematic Review. Chest. 2010 Nov 11. [Epub ahead of print]
Category: Critical Care
Posted: 12/15/2010 by Mike Winters, MBA, MD
(Updated: 7/16/2024)
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The Importance of Antibiotic Timing for Sepsis and Septic Shock
Funk DJ, Kumar A. Antimicrobial therapy for life-threatening infections: Speed is life. Crit Care Clin 2011; 27:53-76.
Category: Critical Care
Keywords: Antibiotics, linezolid, serotonin syndrome, delirium, critical care (PubMed Search)
Posted: 12/7/2010 by Haney Mallemat, MD
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Linezolid is used for gram-positive infections resistant to conventional therapy (e.g., Vancomycin-resistant enterococcus and Methicillin Resistant Staph Aureus). Linezolid is an oxazolidinone, but more importantly it is a weak monoamine oxidase inhibitor (MAOI) and serotonin syndrome (e.g., altered mental status, neuromuscular abnormalities, autonomic instability) may occur when combined with selective serotonin re-uptake inhibitors (SSRIs) or with recent discontinuation of SSRI.
Be aware that the following drugs can precipitate serotonin syndrome when combined with Linezolid:
Mirtazpine Buproprion Fentanyl
Trazodone Buspirone Bromocryptine
Levodopa Lithium Amphetamines
Cocaine Codeine Reserpine
Ergots MAOI's
Narita, M. Linezolid-Associated Peripheral and Optic Neuropathy, Lactic Acidosis, and Serotonin Syndrome Pharmacotherapy (2007) vol. 27 (8) pp. 1189-97
Category: Critical Care
Posted: 11/30/2010 by Mike Winters, MBA, MD
(Updated: 7/16/2024)
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Beware Trendelenburg Positioning in the Critically Ill Obese Patient
Rahman O, Willis L. Vascular procedures in the critically ill obese patient. Crit Care Clin 2010;26:647-60.
Category: Critical Care
Keywords: Status epilepticus, non-convulsive, altered mental status, seizure, critical care, ICU, neurology (PubMed Search)
Posted: 11/23/2010 by Haney Mallemat, MD
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Non-Convulsive Status Epilepticus (NCSE) is generally under reported. An ICU study found 10% admissions for altered mental status (AMS) were eventually diagnosed as NCSE.
Pearls:
- Include NCSE in the AMS differential
- NCSE may occur with or without convulsive seizures
- Difficult to distinguish from a post-ictal state (14% of convulsive seizures convert to
NCSE)
- Reported mortality is up to 44%
Consider NCSE when:
- Seizure history / recent seizures
- Post-ictal period >1 hour
- Odd behaviors (e.g., chewing, blinking, personality change) and abnormal eye
movements (86% specific)
- AMS without structural, metabolic or traumatic etiology
- Patient intubated for status epilepticus
If you are unsure but suspicious of NCSE order a STAT EEG. Treat NCSE like a convulsive status.
Slattery, D. Seizures as a cause of altered mental status. Emerg Med Clin North Am. 2010 Aug;28(3):517-34.
Category: Critical Care
Posted: 11/16/2010 by Mike Winters, MBA, MD
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Positioning for Ventilated, Critically Ill Obese Patients
Ashburn DD, DeAntonio A, Reed MJ. Pulmonary system and obesity. Crit Care Clin 2010; 26:597-602
Category: Critical Care
Keywords: ultrasound, ocular, sonography, intracranial pressure, optic nerve sheath, ICP (PubMed Search)
Posted: 11/9/2010 by Haney Mallemat, MD
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Ocular sonography is a fast, simple, and non-invasive tool to detect elevated intracranial pressure (ICP) by measuring the optic nerve sheath diameter (ONSD). Several studies have shown a positive correlation between increased ONSD (>5.7mm) and elevated ICP (>20mmHg). Although ultrasound may not replace CT or MRI to diagnose the cause of the increased ICP, its use as a triage tool can expedite these tests.
The technique:
Please see the references below for more information and, as with any new technique please consult local experts prior to making clinical decisions.
http://www.sonoguide.com/smparts_ocular.html
Soldatos, T. et al. Optic nerve sonography in the diagnostic evaluation of adult brain injury. Crit Care. 2008; 12(3): R67. Epub 2008 May 13.
Category: Critical Care
Posted: 11/2/2010 by Mike Winters, MBA, MD
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Ventilation Pearls in the Post-Cardiac Arrest Patient
Peberdy MA, Callaway CW, Neumar RW, et al. Post cardiac arrest care: 2010 American Heart Association guidelines for cardiopulmonary resuscitation and emergency cardiovascular care. Circulation 2010;122(S3):S768-S786.