Category: Pediatrics
Keywords: Ultrasound, pediatrics, appendicitis (PubMed Search)
Posted: 6/20/2014 by Jenny Guyther, MD
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Category: Pediatrics
Keywords: Psychiatric clearance, pediatric (PubMed Search)
Posted: 5/16/2014 by Jenny Guyther, MD
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Mental health-related visits account for 1.6–6% of ED encounters. Patients with acute psychosis are often brought to the ED for clearance prior to psychiatric evaluation. Is this necessary?
Background: Several adult studies have shown that only 0–4% of patients with isolated psychiatric complaints have organic diagnoses requiring urgent treatment. Routine ED laboratory testing in adults is low yield still, with one study identifying abnormalities in only 2 of 352 patients—both mild hypokalemia. A pediatric study found that 207 of 209 patients were medically cleared.
This study was a retrospective review of pediatric psychiatric patients presenting to a an urban California hospital. They examined 798 patients who had an involuntary psychiatric hold placed by a psychiatric mobile response team.
The authors concluded that few pediatric patients brought to the ED on an involuntary hold required a medical screen and perhaps use of basic criteria in the prehospital setting to determine who required a medical screen (altered mental status, ingestion, hanging, traumatic injury, unrelated medical complaint, sexual assault) could have led to significant savings.
Santillanes, G et al. Is Medical Clearance Necessary for Pediatric Psychiatric Patients? J Emerg Med. 2014 Mar 15. pii: S0736-4679(13)01455-8. [Epub ahead of print]
Category: Pediatrics
Keywords: scabies, pediatrics (PubMed Search)
Posted: 4/18/2014 by Jenny Guyther, MD
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Scabies is considered by the WHO to be one of the main neglected diseases with approximately 300 million cases worldwide each year. One third of cases of scabies seen by dermatologists are in kids less than 16 years old. The belief had been that presentation varies by age. One French study reported a first time miss rate of more than 41% and an overall diagnostic delay of 62 days.
A prospective, multi center observational study of patients with confirmed scabies sought to determine common phenotypes in children. All patients were seen by dermatologists in France and administered standard questionnaires. They were divided into 3 age groups, <2 years, 2-15 years and > 15 years. 323 patients were included.
The study found that:
-infants were more likely to have facial involvement and nodules, especially on the back and axilla
-relapse was more common in < 15 year olds - this was hypothesized to be due to poor compliance with treatment to the head
-family members with itch, or planter or scalp involvement were independently associated with diagnosis of scabies in kids < 2 years
-burrows were seen in 78%, nodules in 67% and vesicles of 43% of patients (see photo)
-itching was absent in up to 10% of patients
Bottom line: Have a high suspicion for scabies in any rash.
1404180657_scabies_figures.docx (1,793 Kb)
Category: Pediatrics
Posted: 4/11/2014 by Rose Chasm, MD
(Updated: 8/14/2024)
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Category: Pediatrics
Keywords: Head injury, vomiting, PECARN (PubMed Search)
Posted: 3/21/2014 by Jenny Guyther, MD
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Category: Pediatrics
Keywords: asthma, pediatrics, dexamethasone, prednisone (PubMed Search)
Posted: 3/10/2014 by Danielle Devereaux, MD
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Hot off the press! Pediatrics March 2014 just published results of a meta-analysis that compared 1 or 2 dose regimens of Dexamethasone versus 5 day course of Prednisone/Prednisolone for management of acute asthma exacerbations in pediatric patients. The results showed that Dexamethasone was as efficacious as the longer course of Prednisone. End points used were return trips to the emergency department and hospital admissions. On further review of the literature, parents tend to prefer the shorter duration of therapy with Dexamethasone. Also, there is less vomiting associated with Dexamethasone. There have been several articles published that show Dexamethasone is more cost-effective than Prednisone. Bottom line: consider giving single dose of Dexamethasone in the ER and then sending patient home with 1 additional dose.
Keeney G, Gray M, Morrison A, et al. Dexamethasone for Acute Asthma Exacerbations in Children: A Meta-analysis, Pediatrics March 2014, pp 493-499.
Williams K, Andrews A, Heine D, et al. Parental Preference for Short versus Long Course Corticosteroid Therapy in Children With Asthma Presenting to the Pediatric Emergency Department, Clinical Pediatrics January 2012, pp 30-34.
Andrews A, Wong K, Heine D, et al. A Cost-effectiveness Analysis of Dexamethasone versus Prednisone in Pediatric Acute Asthma Exacerbations, Annals of Emergency Medicine July 2012, pp 943-949
Category: Pediatrics
Keywords: Passive leg raise, hypotension (PubMed Search)
Posted: 2/21/2014 by Jenny Guyther, MD
(Updated: 8/14/2024)
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Passive leg raise (PLR) has been studied in adults as a bedside tool to predict volume responsiveness (see previous pearls from 5/7/13 and 6/17/2008). Can this be applied to children?
A single center prospective study looked at 40 intensive care patients ranging in age from 1 month to 12.5 years. They used a noninvasive monitoring system that could measure heart rate, stroke volume and cardiac output. These parameters were measured at a baseline, after PLR, after another baseline and after a 10 ml/kg bolus.
Overall, changes in the cardiac index varied with PLR. However, there was a statistically significant correlation in children over 5 years showing an increase in cardiac index with PLR and with a fluid bolus.
Bottom line: In children older then 5 years, PLR can be a quick bedside tool to assess for fluid responsiveness, especially if worried about fluid overload and in an under served area.
Lu et al. The Passive Leg Raise Test to Predict Fluid Responsiveness in Children - Preliminary Observations. Indian J Pediatr. Dec 2013. (epub ahead of print).
Category: Pediatrics
Keywords: metabolic, inborn errors of metabolism, hyperammonemia (PubMed Search)
Posted: 2/14/2014 by Danielle Devereaux, MD
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Inborn errors of metabolism (IEM) are rare, each typically affecting 1 in 5000 to 1 in 100,000 children, BUT collectively these disorders are more common because there are so many. If you are lucky…when they present to the ED they come with a letter from Dr. Greene (our world renowned metabolic geneticist) detailing exactly what to do. The rest of the time…you are on your own. Think about IEM in any neonate or child with history of feeding difficulties, failure to thrive, recurrent vomiting, unexplained altered mental status and/or acidosis. Pay particular attention to feeding difficulties that appear with changes in diet: switch from soy to cow’s milk formula (galactose), addition of juice or fruit or certain soy formulas (fructose), switch from breast milk to formula or foods (increased protein load), and longer fasting periods from sleeping or illness.
For this pearl, we will focus on primary hyperammonemia from an enzymatic block in ammonia metabolism within the urea cycle. It is important to remember that secondary hyperammonemia can result from metabolic defects such as organic acid disorders, fatty acid oxidation disorders, drugs that interfere with urea cycle, or severe liver disease. Amino acids liberated from excess protein breakdown (stress of newborn period, infection, injury, dehydration, surgery, or increased intake) release nitrogen which circulates as ammonia. Ammonia is then converted to urea via the urea cycle and excreted in the urine. With urea cycle defects (UCD) there is an enzymatic block in the cycle that results in accumulation of ammonia which has toxic effects on the CNS especially cerebral edema. The most common UCD is ornithine transcarbamylase deficiency followed by argininosuccinic academia, and citrullinemia.
Clinical presentation includes poor feeding, lethargy, tachypnea, hypothermia, irritability, vomiting, ataxia, seizures, hepatomegaly, and coma. Hyperammonemic crises in neonates mimic sepsis! If you think about an IEM in your differential, send plasma ammonia (1.5 mL sodium-heparin tube on ice STAT), plasma amino acids, and urine organic acids. Other helpful labs include blood gas, CMP, urinalysis (looking at ketones), lactate, plasma acylcarnitines, and newborn screen if not already sent. Plasma ammonia is a direct index of CNS toxicity and important to follow for acute management. Serum level > 150 in sick neonate or > 100 in sick infant/child is concerning for IEM. The presence of hyperammonemia and respiratory alkalosis suggest urea cycle defect. The presence of metabolic acidosis and hyperammonemia suggests organic acid disorder.
Immediate treatment of hyperammonemia is critical to prevent neurologic damage. Cognitive outcome is inversely related to the number of days of neonatal coma caused by the cerebral edema.
1. Stop all protein intake! You need to stop catabolism.
2. Start D10 at 1.5 times maintenance rate with GIR at least 6-8. Start intralipids 1-3g/kg/day when able (typically in the ICU after central line placed).
3. Give ammonia scavenger medications sodium benzoate and sodium phenylacetate. These are available commercially as Ammonul.
a. 0-20kg: 2.5mL/kg IV bolus over 90 min followed by same dose as 24 hr infusion
b. >20kg: 55 mL/m2 IV bolus over 90 min followed by same dose as 24 hr infusion
4. HEMODIALYSIS! Dialysis is the most effective way to remove ammonia and should be done when level > 300. The decision to hemodialyze is crucial in preventing irreversible CNS damage; when in doubt in the face of elevated ammonia, HEMODIALYZE!
Category: Pediatrics
Posted: 2/7/2014 by Rose Chasm, MD
(Updated: 8/14/2024)
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Cruz AT, Perry AM, Williams EA, et al. Implementaion of Goal-Directed Therapy for Children With Suspected Sepsis in the Emergency Department. Pediatrics 2011;127;e758.
Category: Pediatrics
Keywords: hyponatremia, maintenance fluid (PubMed Search)
Posted: 1/17/2014 by Jenny Guyther, MD
(Updated: 8/14/2024)
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Wang et al. Isotonic Versus Hypotonic Maintenance IV Fluids in Hospitalized Children: A Meta-Analysis. Pediatrics 2014; 133;105.
Category: Pediatrics
Keywords: Pediatrics, head lice (PubMed Search)
Posted: 1/6/2014 by Danielle Devereaux, MD
(Updated: 8/14/2024)
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Head lice infestation is a common problem in the United States with treatment costs estimated at 1 billion dollars and cases affecting millions of children each year. Many of these children present to the ED for care...lucky us! Traditional therapies containing permethrin and pyrethrins are having increased rates of treatment failure likely secondary to increasing resistance and medication noncompliance. The typical first line agents require multiple doses. There are safety concerns regarding therapies that contain malathion and lindane in children. Is there another option? Topical ivermectin 0.5% lotion applied to scalp in a single dose has been shown to be effective and safe for treatment of head lice infestation in children older than 6 months. It was FDA approved at the end of 2012. Considerations include cost. Sklice lotion is expensive!
The NEJM article was considered an "editors pick" by the AAP as one of the best articles of 2012-2013.
1. Pariser DM, Meinking TL, Bell M, et al. Topical 0.5% ivermectin lotion for treatment of head lice. N Eng J Med. 2012; 367(18):1687-1693
2. Wright, T. Topical Ivermectin: a new treatment for head lice. AAP Grand Rounds, Feb 2013, Vol 29(2)
3. Frankowski BL, et al. Head Lice. Pediatrics. 2010; 126:392-404
4. Meinking TL, et al. Head Lice. Pediatric Dermatology. 2010; 27(1):19-24
Category: Pediatrics
Posted: 12/27/2013 by Mimi Lu, MD
(Emailed: 12/28/2013)
(Updated: 12/28/2013)
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Category: Pediatrics
Posted: 12/20/2013 by Jenny Guyther, MD
(Updated: 8/14/2024)
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Category: Pediatrics
Posted: 12/13/2013 by Rose Chasm, MD
(Updated: 8/14/2024)
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Wang CJ, et al. Quality-of-care indicators for children with sickle cell disease. Pediatrics. 2011;128:484.
Berini JC, et al. Fatal hemolysis induced by Ceftriaxone in a child with sickle cell anemia. 1995;126:813.
Category: Pediatrics
Keywords: trauma, cardiac arrest, return of spontaneous circulation (PubMed Search)
Posted: 11/22/2013 by Mimi Lu, MD
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Category: Pediatrics
Keywords: Intussusception, abdominal pain, fever (PubMed Search)
Posted: 11/10/2013 by Jenny Guyther, MD
(Emailed: 11/15/2013)
(Updated: 11/16/2013)
Click here to contact Jenny Guyther, MD
Case: A 3 year 9 month female presents with fever to 39.4 C and intermittent abdominal pain worsening over 2 days. The patient had been tolerating food and had no change in her bowel habits. Based on the imaging below, what is your diagnosis and treatment?
Answer: Intussusception. This patient failed air reduction enema and was taken the OR. No bowel ischemia was found. The ilium was inside of the colon at the ileocecal valve. There was significant mesenteric lymphadenitis noticed. The patient recovered and was discharged later that day.
The x-ray above shows a soft tissue mass under the liver projection in the RUQ that can be suggestive of intussusception in the appropriate case. The second x-ray done during attempted air reduction shows air surrounding a dense area on the right side. Ultrasound, however, has become the gold standard. The ultrasound image shows the classic target sign of hyperechoic compressed loop of bowel telescoping within a hypoechoic edematous outer loop of bowel.
A few other important facts:
The median age of presentation is 32 months, with many presenting before 12 month.
Abdominal pain and/or crying was seen in 95% of cases. 66% had vomiting, 28% had fever, and 27% had bloody stools.
Causes included 29% with enlarged mesenteric lymph nodes (followed by GJ tube obstruction and meckels diverticulium)
30% have concurrent infections (URI and gastroenteritis being most common)
91% 1st time success rates with air contrast enema
*The above percentages were taken from the article referenced, which is a retrospective review done at a tertiary pediatric center.
Lochhead et al. Intussusception in children presenting to the emergency department. Clinical Pediatrics 2013 52:1029.
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Category: Pediatrics
Keywords: cough, upper respiratory infection, children, honey (PubMed Search)
Posted: 11/1/2013 by Danielle Devereaux, MD
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How many times have you been frustrated in the peds ED when you have a child with a URI that has a significant night time cough and you feel like you have nothing to offer them for symptom control? The parent is frustrated because the child is not sleeping which means they are not sleeping and they are looking at you for help. We all know that OTC cough and cold medications are not helpful and may be harmful in children <2 yrs old and should be used with caution in children <6 yrs old. So what can you do? You can recommend a course of HONEY at night. Of course this does not apply to children < 1 yr who are at increased risk of botulism. A recent double-blind placebo-controlled trial published in Pediatrics in 2012 demonstrated reduced night time cough and subjective improved sleep quality in children age 1-5 who were given honey compared to placebo. This study supports previous less rigorous publications that found honey was an effective remedy on cough in children. Mechanism for honey's beneficial effect on cough is unknown but possibly related to close anatomic relationship between sensory nerve fibers that initiate cough and gustatory nerve fibers that taste sweetness. Of note, a recently published survey in Pediatric Emergency Care revealed that 2/3 of parents were unaware of the FDA guidelines regarding OTC cough and cold remedies in children! After you recommend HONEY for night time cough, take an extra minute and educate your parents about the potential dangers of cough and cold medicines in small children!
Cohen A, Rozen J, Kristal H, et al. Effect of honey on nocturnal cough and sleep quality: a double-blind, randomized, placebo-controlled study. Pediatrics. 2012; 130(2): 465-471.
Varney SM, et al. Pediatr Emerg Care. 2012; 28(9): 883-885
Food and Drug Administration. Using Over-The-Counter Cough and Cold Products in Children. Available at http://www.fda.gov/ForConsumers/ConsumerUpdates/ucm048515.htm
Category: Pediatrics
Keywords: skull fracture (PubMed Search)
Posted: 10/18/2013 by Jenny Guyther, MD
(Updated: 8/14/2024)
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Pediatric patients with an isolated skull fracture and normal neurological exam have a low risk of neurosurgical intervention and outpatient follow up may be appropriate (assuming no suspicion of abuse and a reliable family). In a study published in 2011, a retrospective review over a 5 year period at a level 1 trauma center showed that 1 out of 171 admitted patients with isolated skull fractures developed vomiting. This patient had a follow up CT showing a small extra-axial hematoma that did not require intervention. 58 patients were discharged from the ED within 4 hours.
You can also check out another recent article published in Annals of Emergency Medicine on the same topic this month!
Rollins et al. Neurologically intact children with an isolated skull fracture may be safely discharged after brief observation. Journal of Pediatric Surgery. Volume 26. Issue 7. 2011.
Mannix et al. Skull Fractures: Trends in Management in US Pediatric Emergency Departments. Annals of Emergency Medicine. Volume 64. Issue 4. 2013.
Category: Pediatrics
Keywords: Omphalitis, necrotizing fasciitis, umbilical cord (PubMed Search)
Posted: 10/4/2013 by Joey Scollan, DO
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Should you be concerned about erythema around the umbilical stump?!
Yes!
Often parents will bring their neonate to the ED with concerns about the umbilical cord and it is just a simple granuloma or normal detachment. But is it omphalitis???
Omphalitis incidence is low in developed countries, but that means it’s easier, and no less catastrophic, to miss!
Omphalitis is a superficial cellulitis of the umbilical cord, but 10-16% progress to necrotizing fasciitis of the abdominal wall!!!
Always ADMIT and consider consulting surgery early in case of rapid progression…
Most often polymicrobial and should be treated with:
Should notice improvement within 12-24 hours, so if don’t or begin to observe
CONSULT SURERY for concern of necrotizing fasciitis which has a mortality rate of close to 60%!!!
Category: Pediatrics
Keywords: orthopedics, compartment syndrome (PubMed Search)
Posted: 9/20/2013 by Jenny Guyther, MD
(Updated: 8/14/2024)
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We have learned how to diagnose compartment syndrome in adults, but how do you determine the early warning signs in a nonverbal or even frightened child?
Rising compartment pressures are related to increasing anxiety and agitation in children. A Boston study in 2001 showed that increasing pain medication requirements were detected 7 hours earlier than a vascular exam change. 90% of the patients with compartment syndrome in this study reported pain, but only 70% had another ‘P” (pallor, parasthesia, paralysis or pulselessness).
This has led to the proposal of the 3 “A”s for early identification of compartment syndrome in children: increasing anxiety, agitation and analgesia requirement.
Noonan and McCarthy. Compartment Syndrome in Pediatric Patients. Journal of Pediatric Orthopedics. Vol 30. No 2. March 2010.