Category: Critical Care
Keywords: Vitamin D, critically ill (PubMed Search)
Settings: multicenter, double-blind, phase 3 trial (apparently vitamin D worked in phase 2 trials).
Early administration of high dose vitamin D did not improve 90-day all cause mortality.
Early High-Dose Vitamin D3 for Critically Ill, Vitamin D-Deficient Patients.
National Heart, Lung, and Blood Institute PETAL Clinical Trials Network, Ginde AA, Brower RG, Caterino JM, Finck L, Banner-Goodspeed VM, Grissom CK, Hayden D, Hough CL, Hyzy RC, Khan A, Levitt JE, Park PK, Ringwood N, Rivers EP, Self WH, Shapiro NI, Thompson BT, Yealy DM, Talmor D. N Engl J Med. 2019 Dec 26;381(26):2529-2540.