UMEM Educational Pearls - Critical Care

Category: Critical Care

Title: VA ECMO in Pulmonary Embolism

Keywords: ECMO, PE, hypotension (PubMed Search)

Posted: 10/18/2016 by Daniel Haase, MD (Updated: 4/10/2018)
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Takeaways

--Massive PE is defined as PE with obstructive shock (hypotension [SBP <90] or end-organ malperfusion)

--Consider venoarterial (VA) ECMO in massive PE for hemodynamic support, particularly prior to intubation

--VA ECMO may prevent intubation/mechanical ventilation, surgical intervention, systemic and local thrombolysis

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Category: Critical Care

Title: Oxygen-ICU

Posted: 10/11/2016 by Mike Winters, MD (Updated: 10/18/2019)
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Takeaways

Oxygen-ICU Trial

  • Recent observational trials have demonstrated an association between hyperoxia and worse outcomes in select critically ill patient populations.
  • The Oxygen-ICU Trial was just published online in JAMA, and was an RCT to assess whether a conservative protocol for oxygen supplementation could improve outcomes in critically ill ICU patients compared with usual care.
  • A total of 236 patients were randomized to the conservative oxgyen group (PaO2 target 70-100 mm Hg, SpO2 94-98%), whereas 244 were randomized to the usual care group (PaO2 up to 150 mm Hg, SpO2 97-100%).
  • The results demonstrated that ICU mortality was lower in patients treated witih a conservative oxygen strategy, with an absolute risk reduction of 8.6%.
  • Take Home Point: Be careful with the tiration of oxygen therapy and avoid hyperoxia in many of your critically ill patients.

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The delta gap is a measurement intended to assess for mixed acid-base disorders. A straightforward alternative, the strong ion difference (SID), allows for a quick and simple assessment of any non-gap acidosis or alkalosis that may be present.

The SID is simply the difference between the strong cations (Na+, K+, Mg+, Ca+) and the strong anions (Cl-) present in the serum. The abbreviated SID is the difference between the serum sodium and serum chloride levels (approximately 138-102). Values typically range from 36-40 mg/dl. Values less than 36 denote the presence of some degree of hyperchloremic, non-gap, acidosis. While values greater than 40 demonstrate the presence of hypochloremic, non-gap, alkalosis. And while on rare occasions, variations in albumin or elevated levels of cations other than sodium can lead you astray, the SID is as accurate as a delta gap at identifying mixed acid-based disorders without the added mathematical complexity.

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Category: Critical Care

Title: High Chloride Load Associated with Increased Mortality

Keywords: Fluids, Fluid resuscitation, Metabolic Acidosis (PubMed Search)

Posted: 9/27/2016 by Daniel Haase, MD
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Takeaways

TAKE HOME POINTS:

-- High chloride load is associated with adverse outcomes in large-volume resuscitation (>60mL/kg in 24h), including increased risk of death [1]

-- Avoid supraphysiologic chloride solutions (i.e. normal saline) when resuscitation volumes are likely to exceed 60mL/kg (e.g. sepsis, DKA)

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Category: Critical Care

Title: Passive Leg Raise

Keywords: passive leg raise, arterial pressure, pulse pressure variation, volume responsiveness, fluid resuscitation (PubMed Search)

Posted: 9/20/2016 by Mike Winters, MD
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Pitfalls with PLR

  • The passive leg raise (PLR) test has become a popular method to assess volume responsiveness in critically ill patients.
  • PLR mobilizes a volume of approximately 150-300 mL and can be used in spontaneously breathing patients, those receiving positive pressure ventilation, or those with various arrhythmias. 
  • In order to properly perform the PLR, you must have a method to monitor cardiac output. (See previously pearl on 7/26/16).
  • Pitfall: Simply monitoring arterial blood pressure alone is not a sufficient method to assess a positive PLR.
  • Pitfalls:Risks of performing a PLR include increased intracranial pressure, reduced cerebral blood flow, and decreased pulmonary compliance.

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Category: Critical Care

Title: Blood Pressure Management in Intracerebral Hemorrhage (ICH)

Keywords: Intracerebral hemorrhage, intraparenchymal hemorrhage, ICH, IPH, hypertensive emergency, blood pressure, neurocritical care, nicardipine (PubMed Search)

Posted: 8/15/2016 by Daniel Haase, MD (Emailed: 9/6/2016) (Updated: 9/6/2016)
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Question

--Aggressive BP management (SBP <140) in atraumatic intracerebral hemorrhage (ICH) does NOT signifcantly improve mortality or disability compared with traditional goal (SBP <180) [1]

--However, a lower goal (SBP <140) has been shown to decrease hematoma size and be safe compared to a higher goal (SBP <180) [2]

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Category: Critical Care

Title: Refractory Status Epilepticus

Keywords: refractory status epilepticus, ketamine, propofol, siezure, midazolam (PubMed Search)

Posted: 8/30/2016 by Mike Winters, MD
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Ketamine for RSE?

  • Up to 43% of patients with status epilepticus may progress to refractory status epilepticus (RSE).
  • Propofol, midazolam, and barbituates are often recommended for patients with RSE.
  • Importantly, all of these medications may be limited by hypotension and respiratory depression.
  • Ketamine is emerging as adjuvant therapy for patients with RSE.
  • The loading dose of ketamine ranges from 0.5 to 3 mg/kg, followed by a maintenance infusion of 0.3 to 4 mg/kg/h.

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Is it possible to have a patient present in diabetic ketoacidosis (DKA) with both negative serum and urinary ketone levels?

A case report published in American Journal of Emergency Medicine by Jehle et al provides a helpful reminder of this phenomenon (1). The degree of acidosis is directly related to the ratio of the various ketones/ketone metabolites: acetone, acetoacetate and beta-hydroxybutyrate present in the serum. The proportion of each respective substance is determined by the existing redox state in the blood. At any given time, acetoacetate and beta-hydroxybutyrate exist in an equilibrium dependent upon the ratio of NAD+ and NADH(fig.1). These substances freely convert with the assistance of the enzyme beta-hydroxybutyrate dehydrogenase (2). This conversion requires the donation of a hydrogen atom from NADH. The balance between beta-hydroxybutyrate and acetoacetate, is determined by the ratio of NADH to NAD+. Acetoacetate will freely degrade into acetone through non-enzymatic decarboxylation. Early in DKA, acetoacetate is the most prevalent substance. As the disease progresses and the serum ratio of NADH to NAD+ increases, the proportion of beta-hydroxybutyrate rises, decreasing the quantity of acetoacetate and acetone.

Traditional serum and urinary ketone assays react strongly to acetoacetate but neither reliably react with beta-hydroxybutyrate. Patients in whom the majority of their anion gap is filled by beta-hydroxybutyrate, urinary or serum ketone levels may be negative. In such cases, serum beta-hydroxybutyrate assays would be positive but are not universally available.

It is important to note, with resuscitation and insulin therapy, the ratio of NADH/NAD+ will start to normalize causing an increase in the quantity of acetoacetate. As the patient improves and the anion gap clears, the degree of ketones detected in the serum and urine will paradoxically increase.

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Category: Critical Care

Title: A Warning to Critical Care Physicians

Keywords: Zika Virus, Guillain-Barre (PubMed Search)

Posted: 8/9/2016 by Mike Winters, MD
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Zika Virus-associated GBS

  • Zika virus has been shown to trigger Guillain-Barre Syndrome (GBS) at a rate similar to Campylobacter jejuni infections.
  • In patients with Zika virus-associated GBS, neurologic deterioration has been rapid, with approximately 33% of patients developing respiratory distress.
  • For patients who have required intubation, the duration of mechanical ventilation and length of ICU stay has been very long.
  • Consider Zika virus-associated GBS in patients with muscle weakness, facial palsy, or paresthesias in the setting of a travel or exposure history to the virus.

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Despite a lack of prospective data, end-tidal CO2 (ETCO2) is often proposed as a viable replacement for the traditional pulse check to identify return of spontaneous circulation (ROSC) in patients presenting to the Emergency Department in Cardiac Arrest. A recent study by Tat et al examined this very question. The authors prospectively enrolled 178 patients suffering out-of-hospital cardiac arrest (OHCA) and examined the accuracy of a rise in ETCO2 at predicting ROSC. The authors examined both a rise of 10 and 20 mm Hg in ETCO2. Of the 178 patients included in this cohort, 60 (34%) experienced ROSC. The sensitivity and specificity of ETCO2 to predict ROSC at a threshold of 10 mm Hg was 33% and 97% respectively. At a threshold of 20 mm Hg ETCO2 performed no better with a sensitivity and specificity of 20% and 99% respectively.

What this data suggests is while a rise of ETCO2 of greater than 10 is highly suggestive of ROSC, the contrary cannot be said. The absence of a spike in ETCO2 does not rule out ROSC, as the large majority of patients experiencing ROSC in this cohort did so without demonstrating a significant rise in ETCO2. This evidence suggests that ETCO2 is a poor surrogate for a pulse check.

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Predicting Fluid Responsiveness with ETCO2

  • It is well known that almost 50% of critically ill patients do not respond to fluid resuscitaiton. For those that do not respond, indiscriminate fluid administration may be harmful.
  • There is increasing emphasis on the use of dynamic markers of fluid responsiveness, namely passive leg raise (PLR), pulse pressure variation, respirophasic changes in the IVC, and many others.
  • ETCO2 can also be used to assess fluid responsiveness in mechanically ventilated patients with no spontaneous respiratory effort.
  • An increase in ETCO2 of at least 5% with a PLR has been shown to outperform arterial pulse pressure as a measure of fluid responsiveness.

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Fentanyl and the Neurologically Injured Patient
  • Emergency providers routinely care for neurologically injured patients, such as those with a SAH or TBI.
  • Many of these patients will require airway management. In these patients, it is important to minimize any increase in ICP, as this can adversely effect cerebral perfusion pressure.
  • When intubating the neurocritical care patient, consider a dose of fentanyl (2 to 5 mcg/kg) prior to intubation. This has been shown to decrease the sympathomimetic response to laryngoscopy.

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LVADs and RV Failure

  • Acute RV failure can be seen in up to 10% of patients after LVAD implantation.
  • The treatment of RV failure in the LVAD patient consists of the following:
    • Fluids: avoid aggressive fluid administration, as this can displace the septum and impair LVAD function
    • Inotropes: consider early initiation of dobutamine, milrinone, or epinephrine to augment RV function
    • Vasopressors: target a MAP higher than 60 to 70 mmHg to maintain RV perfusion pressure
  • If intubated, avoid hypoxia, hypercarbia, high PEEP, and high ventilator pressures.  These can increase pulmonary vascular resistance and further worsen RV function.

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Category: Critical Care

Title: Types of Respiratory Failure

Keywords: Respiratory failure (PubMed Search)

Posted: 6/21/2016 by Feras Khan, MD
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There are 4 types of respiratory failure that all providers should be familiar with

Type 1: Hypoxemic, PaO2 <50; this can include shunt , V/Q mismatch, or high altitude. Pulmonary edema, ARDS, pneumonia are common causes of this type of failure.

Type 2: Hypercapnic respiratory failure; decreased RR or tidal volume. This includes neuromuscular disorders including GBS or Myasthenia Gravis, in addition to medication overdose. COPD and asthma can lead to this type of respiratory failure as well.

Type 3: Peri-operative; atelectasis; decreased FRC from being supine or obese during the operative period.

Type 4: Shock or hypoperfusion leading to increased work of breathing and respiratory failure.


Heat Stroke

  • Heat stroke is critical illness defined as a core body temperature greater than or equal to 40oC and altered level of consciousness.
  • Mortality from heat stroke can be as high as 30%.
  • Numerous methods exist to rapidly cool patients below 39oC.
  • Of these methods, ice-water immersion cools patients the fastest and is highly effective in young patients with exertional heat stroke.
  • There is currently insufficient evidence to routinely recommend antipyretic agents, intravascular cooling devices, body cavity lavage, or the use of ice packs in the groin/axilla/neck. In addition, dantrolene is not recommended in the treatment of heat stroke.

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  • Current guidelines recommend IV proton pump inhibitors in setting of acute upper GI hemorrhage as a bolus + infusion (e.g. 80 mg bolus + 8mg/hr infusion).
  • Recent meta-analysis comparing bolus + infusion versus intermittent bolus (most commonly 40 mg BID) demonstrated non-inferiority of intermittent bolus dosing.
  • In fact, there was a trend (though not significant) to superiority of intermittent bolus dosing, with decreases in rebleeding, mortality, repeat intervention.
  • From a practical standpoint, pantoprazole requires a dedicated IV line, and is not compatible with other common ICU infusions (fentanyl, propofol, norepinephrine, octreotide).

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  • Many clinicians use end-tidal CO2 to monitor respirations during procedural sedation or mechanical ventilation
  • Typically either the presence (or absence) of a "normal" waveform or the quantitative value is used, however a lot more information can be gathered from the actual shape of the waveform; below are a few examples.
  • For more examples of interpreting waveforms, click HERE.

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Category: Critical Care

Title: American Thoracic Society (ATS) Conference Highlights

Keywords: ATS, non invasive ventilation, aspirin, nighttime extubation, dialysis (PubMed Search)

Posted: 5/24/2016 by Feras Khan, MD (Updated: 10/18/2019)
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American Thoracic Society (ATS) Conference Highlights

The ATS conference was last week in San Francisco and a few cool articles were presented. They are briefly summarized below:

1.     Using a helmet vs face mask for ARDS: Non-invasive ventilation is not ideal for ARDS for a variety of reasons. At the same time, endotracheal intubation and ventilation carries some risks as well. Could a new design of a "helmet" device make a difference? This one center study from the Univ of Chicago suggests that it would: decreased rate of intubation, increase in ventilator free days, and decrease in 90 day mortality. http://jama.jamanetwork.com/article.aspx?articleid=2522693

2.     Can aspirin prevent the development of ARDS in at risk patients in the emergency department? Unfortunately, it does not appear to help. http://jama.jamanetwork.com/article.aspx?articleid=2522739

3.     Should you start renal-replacement therapy (HD, CRRT etc) in critically ill patients with AKI sooner or later? Seems to have no difference and may actually lead to patients not needing any dialysis. Really a great read  if you have time.  http://www.nejm.org/doi/full/10.1056/NEJMoa1603017?query=OF&

4.    Should I extubate at night? Lastly, probably don’t extubate at night if you can avoid it. Or just be cautious. http://www.atsjournals.org/doi/abs/10.1164/ajrccmconference.2016.193.1_MeetingAbstracts.A6150

 


Situations Where ECMO Will Likely Fail

  • As many EDs and ICUs begin to develop protocols for the use of ECMO, it is important to note select conditions when this therapy is unlikely to be succesful.
    • Chronic respiratory or cardiac disease with no hope of recovery
    • OHCA with prolonged no blood flow
    • Severe aortic regurgitation
    • Type A aortic dissection
    • Refractoroy septic shock with preserved LV function
    • Stem cell transplant patients
    • Advanced age with ARDS
    • Prolonged pre-ECMO mechanical ventilation (> 7 days)
    • Center inexperienced with ECMO

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Category: Critical Care

Title: Zika Virus -- More than Fetal Microcephaly

Keywords: Zika, Guillain-Barre, GBS, ITP, Critical Care (PubMed Search)

Posted: 5/10/2016 by Daniel Haase, MD
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Zika virus has received significant media attention in the US due to its recent link with teratogenicity. But Zika is also associated with critical and life-threatening complications, including death. Differentiating it from other Flavivirus diseases such as Dengue or Chikungunya can be challenging.

Diagnosis

  • Clinical -- low-grade fever, maculopapular pruritic rash, arthralgias (small joints of hands and feet), non-purulent conjunctivitis [1,4]
  • Serum RT-PCR
  • Dengue --high fever, severe myalgias, no conjunctivitis, cytopenia common [2,4]
    • Dengue is a hemorrhagic fever, Zika and Chikungunya are not.
  • Chikungunya -- high fever, severe polyarthralgias, no conjunctivitis, no hemorrhage [2,4]

Complications

  • Guillian-Barre Syndrome (GBS) [1,3]
    • Responsible for majority of Zika deaths worldwide
    • Estimated at 1 in 4000 cases of Zika in French Polynesian study [3]
    • WHO estimates up to 4M cases in the Americas this year (~1k cases GBS)
  • Immune Thrombocytopenic Pupura (ITP) [2]
    • Thrombocytopenia leading to bleeding. Responsible for lone US death and deaths in Columbia
  • Meningoencephalitis, transverse myelitis, fetal microcephaly [2]

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