UMEM Educational Pearls

While chest X ray (CXR) is routinely obtained in the setting of traumatic injury, ultrasound (US) is a fast and reliable way to evaluate for life-threatening traumatic injuries requiring emergent intervention, and is supported by the Eastern Association for the Surgery of Trauma (EAST) guidelines. A recent Cochrane Review compared the test characteristics of chest US vs CXR for detection of traumatic pneumothorax when using Chest CT or thoracostomy as the gold standard.

  • Primary end point: sensitivity and specificity for pneumothorax
  • US performed by nonradiologists.
  • 9 studies, 1271 patients, 410 of which had a pneumothorax
  • Summary sensitivity: US 0.91 (95% CI 0.85-0.94), ranging from  0.82-0.98 in the included studies, vs. CXR 0.47 (95% CI 0.31- 0.63) ranging from 0.09 to 0.75
  • Summary specificity: US 0.99 (95% CI 0.97-1.00, ranging from  0.96-1.00 vs. CXR 1.00 (95% CI 0.97- 1.00), ranging from 0.98 to 1.00

There possible weaknesses of this study, including blinding in the original studies, and several studies may or may not have been at risk for bias as their risk of bias was ‘unclear’.  However, the results were consistent across the studies analyzed and remained similar after sensitivity analysis.

Several anatomical as well as patient care issues may confound US findings for pneumothorax such as the presence of bleb, prior thoracic surgery or pathology, as well as main stem intubation.

Bottom line:  While the presence of pneumothorax is on either CXR or US is highly likely to represent the a true pneumothorax, ultrasound is a far superior screen for the detection of pneumothorax in the trauma patient.

 

 

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Category: Orthopedics

Title: The association between fluoroquinolone use and tendon injury in an adolescent population

Keywords: tendon, antibiotics, tendonitis (PubMed Search)

Posted: 5/22/2021 by Brian Corwell, MD (Emailed: 10/31/2024) (Updated: 10/31/2024)
Click here to contact Brian Corwell, MD

A recent article in Pediatrics attempted to estimate the association between fluoroquinolone use and tendon injury in an adolescent population.

Fluoroquinolones are thought to negatively impact tendons and cartilage in the load-bearing joints of the lower limbs through collagen degradation, necrosis, and disruption of the extracellular matrix.

Population: 4.4 million adolescents aged 12–18 years with filled outpatient fluoroquinolone prescription vs. an oral broad-spectrum antibiotic for comparison.

Fluoroquinolones included ciprofloxacin, levofloxacin, moxifloxacin, and gatifloxacin

Comparator antibiotics included amoxicillin-clavulanate, azithromycin, cefalexin, cefixime, cefdinir, nitrofurantoin, and bactrim.

Outcomes: Primary outcome was 90-day tendon rupture (Achilles, patellar, quadricep, patellar, tibial) identified by diagnosis and procedure codes. Secondary outcome was tendinitis.

Results: The weighted 90-day tendon rupture risk was 13.6 per 100 000 fluoroquinolone-treated adolescents and 11.6 per 100 000 comparator-treated adolescents.

Fluoroquinolone-associated excess risk: 1.9 per 100 000 adolescents; the corresponding number needed to treat to harm was 52 632.

The weighted 90-day tendinitis risk was 200.8 per 100 000 fluoroquinolone-treated adolescents and 178.1 per 100 000 comparator-treated adolescents

Fluoroquinolone-associated excess risk excess risk: 22.7 per 100 000 adolescents; the corresponding number needed to treat to harm was 4405.

Conclusion:

The excess risk of tendon rupture associated with fluoroquinolone treatment was extremely small, and these events were rare. On average, 50,000 adolescents would need to be treated with a fluoroquinolone for 1 additional tendon rupture to occur

The excess risk of tendinitis associated with fluoroquinolone treatment though larger was also small.

Besides tendon rupture, other more common potential adverse drug effects may be more important to consider for treatment decision-making, in adolescents without other risk factors for tendon injury.

 

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Category: Pediatrics

Title: Apnea and bronchiolitis

Keywords: hospitalization, RSV, bronchiolitis (PubMed Search)

Posted: 12/17/2021 by Jenny Guyther, MD (Emailed: 10/31/2024) (Updated: 10/31/2024)
Click here to contact Jenny Guyther, MD

Typical admission considerations for patients with bronchiolitis are work of breathing, hypoxia, and dehydration.  The patients risk of apnea should also be considered.  Younger infants with bronchiolitis are at a risk for apnea.  Studies have cited anywhere from a 16-25% risk in younger infants.  The problem lies in identifying those patients who are at risk and those who are not.  This older study looked at 691 infants and developed criteria which identified all of the 2.7% of patients who developed apnea.
The high risk criteria used in this study were: 1) Full term and younger than 1 month; 2) Born < 37 weeks gestation and younger than 48 weeks post conception or 3) Parents already noted an episode of apnea with this illness.
Bottom line: Incorporate the infants risk of apnea into your disposition decision for patients with bronchiolitis.

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Category: Visual Diagnosis

Title: POCUS: Pulmonary Embolism (Submitted by Alexis Salerno)

Posted: 5/11/2022 by Michael Bond, MD (Emailed: 10/31/2024) (Updated: 10/31/2024)
Click here to contact Michael Bond, MD

Pulmonary Embolism 

  • In patients with high pretest probability and abnormal vital signs think about cardiac evaluation for pulmonary embolism. McConnell’s sign is most specific but can also be found in acute RCA infarct. TAPSE < 1.8 cm is also a good identifier of RV strain. Remember that patients with COPD or Pulm Htn may have RV dilation at baseline. You may also want to risk stratify patients with PE with labs as well as lower extremity dvt studies. 
  • Let’s give a shout out to Ashley Pickering who recently took some awesome echo images of a patient with a known saddle embolism. 

 

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Category: Trauma

Title: Injury score comparable geriatric vs non-geriatric patients: Over 65 years do much worse

Keywords: geriatric, trauma, orthopedic injury, injury severity score (PubMed Search)

Posted: 11/5/2022 by Robert Flint, MD (Emailed: 10/31/2024) (Updated: 12/9/2022)
Click here to contact Robert Flint, MD

Trauma patients over age 65 should be cared for by a multidisciplinary trauma team. Here is another study affirming that patients over age 65 do worse when having similar injuries to those under 65. Interestingly, those under 65 had more operative repairs of their orthopedic injuries as well.  

The authors conclude: “Although the ISS and NISS were similar, mortality was significantly higher among patients aged ≥ 65 years compared to patients < 65 years of age”.

 Also it bears further investigation of why those under 65 received more operative repairs

 

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