BACM stands for benign acute childhood myositis which is typically a benign, viral induced self limiting illness. This was a retrospective study looking at 65 patients in Italy to further characterize the characteristics of the disease.
In this study, the median patient age was 6 years with a male predominance. The incidence of BACM peaked in winter with a second peak in the fall. Patients presented with prodromal symptoms including fever, cough, coryza, sore throat and vomiting. The exam showed difficulty walking and myalgias with reproducible calf tenderness and preserved reflexes. Influenza B and A, COVID and other viral pathogens have been detected in these patients.
Lab work may show an elevated creatinine kinase, AST and potassium. WBC and CRP may also be elevated. The median CK value was 943 U/L and on average normalized within one week. Other studies have shown median CK values in the 3300s. Treatment includes hydration to promote CK clearance and prevent complications including acute kidney injury related to rhabdomyolysis. Recurrent myositis or CK values > 5000 U/L should have screening tests for muscular dystrophy and metabolic disorders.
Bupropion associated cardiac toxicity widens the QRS complex by inhibiting the cardiac gap junction, not cardiac Na channel blockade. NaHCO3 is often administered when EKG changes are noted. But the effectiveness of NaHCO3 in bupropion toxicity is not well established.
A retrospective study between 2010-2020 showed, that administration of NaHCO3 only decreased QRS duration by 2 msec (median). The median NaHCO3 administered was 100 mEq. Although this study was limited by the fact that it only had a small sample size of 13, NaHCO3 administration may provide limited clinical benefit in patients with QRS widening from bupropion overdose.
How many times have you discharged a patient with a clinical impression of “abdominal pain” with no clear explanation or diagnosis?
How many of these times do you direct them to follow up with gastroenterology? And more importantly, how often do they actually do so?
This study discussed a multi-disciplinary approach to ensuring adequate follow up for patients, utilizing an EMR based transition of care (TOC) program. The study stratified patients into 2 groups, pre and post TOC program implementation, to assess rates of appointment scheduling and attendance, as well as rates of return to ED within 30 days. Patients were further stratified based on their Distressed Communities Index (DCI) score (a composite of 7 different socioeconomic metrics) into 5 tiers: Distressed Communities, At Risk Communities, Mid-Tier Communities, Comfortable Communities, and Prosperous Communities. Prior to the implementation of the TOC program, the onus was on the patient to schedule their appointment. The TOC program consisted of an order placed in EMR, which triggered review of the patient's chart by the gastroenterology attending or NP. This individual would then message the information to the appropriate GI subspecialty clinic, along with a time frame in which the patient should be seen. The clinic would then check the patient's insurance reach out to the patient directly to schedule the appointment.
While there was no signifcant difference in 30-day readmission between the pre and post TOC program patients, the post-implementation group was found to both schedule appointments (50% vs 27% p-value <0.01) AND show up to appointments (34% vs 24% p-value <0.01) at significantly higher rates compared to Pre-TOC patients. Additionally, post-TOC patients in the At-Risk and Distressed DCI groups were 22x more likely to follow up than the same groups in the pre-TOC group (OR 22.18, 95% CI 4.23–116.32).
Though the study had promising results, it did admittedly have some limitations, namely the size of the at-risk and distressed groups. Another consideration, though not mentioned in the paper, is that access to a working phone is necessary to the success of this program. Nevertheless, the idea of a TOC program is worth consideration as a means to ensure that patients are not lost to follow up and potentially reduce the risk of adverse events.
These authors performed a scoping review of English language studies involving United States general surgery patients that required transfer to another facility looking at timing of transfer, triage guidelines, and mode of transport . They concluded: “There were mixed results for the impact of transfer timing on outcomes with heterogeneous definitions of delay and populations. Triage guidelines for EGS transfer were consensus or expert opinion. No studies were identified addressing the mode of interfacility EGS transfer.” More research is needed in the area concerning timing, triage and mode of transport for these patients.
Ever see a commercial showing active fit people drinking sugar beverages?
Ever wonder if exercise is protective from the effects of added sugar?
What are the health risks of added sugar?
How much is too much?
C. elegans, a roundworm, shares 40% of its genes with humans
-Frequently used as a model for health and longevity research
In a 2021 study, researchers altered the diet of the roundworms and found that added sugar was linked to increased glycation end products, high levels of which are associated with an increased risk of CV disease, diabetes and Alzheimer’s disease.
Foods such as fruits are high in natural sugars. Added sugars however are “added” by manufactures to increase flavor.
In our diet, added sugars are everywhere from white bread to ketchup to your favorite Starbucks beverage.
-Sugar- sweetened beverages are the largest source of added sugars in the American diet.
In 2016 the FDA added a section on nutritional labels for added sugars.
The CDC advises limitation of added sugars to 10% of total daily caloric intake.
Added sugars (vs. natural sugars) are more likely to cause spikes in blood sugar and create an inflammatory state thereby increasing the risk of numerous medical problems.
A recent study from the Harvard school of public health investigated whether the benefits of physical activity outweigh the risks of CV disease associated with consumption of sugar-sweetened beverages.
Using 2 cohorts (100,000 people) over a 30-year period, those who consumed sugar-sweetened beverages more than twice a week had a higher risk of CV disease.
Those with daily consumption were at higher risk.
Even those that hit the recommended 150 minutes of weekly exercise were not protected.
Physical activity only reduced the risk of CV disease by approximately 50%.
Though the study did not specifically look at sports and energy drinks, these beverages are large sources of added sugars.
For example, A 20-ounce Gatorade's Thirst Quencher contains 36g of sugar.
Take home: Added sugar, even in moderation, may have negative health consequences even in individuals who exercise regularly.
It is an often asked question: should I consider the corrected or the chronologic age when determining the need for fever evaluation in a pediatric patient? The 2021 AAP guidelines for the well appearing febrile neonate are widely accepted and apply to neonates under 60 days. These highly practical guidelines are, unfortunately, not applicable to pre-term neonates. The question often becomes what age to use for a pre-term neonate- the age they actually are, or the age they would be if they had completed a full term gestation.
Hadhud et al attempted to clarify the age utilized in a retrospective review. This looked at febrile 448 pre-term neonates evaluated for fevers. It found that those patients with both a corrected and chronologic age over 3 months had a 2.6% rate of serious bacterial infections or SBI (UTI, bacteremia or meningitis), those with a corrected age under 3 months but a chronologic age over 3 months had a 16.7% rate of SBIs, and those with both a corrected and chronologic age of under 3 months had a 33.3% rate of SBI.
Overall, these rates of infection are higher than the typically reported in febrile neonates, supporting that pre-term neonates have a much higher risk of infections overall. Ultimately, pre-term neonates should be carefully assessed and a more thorough evaluation is typically warranted in this patient population even if they have reached the generally accepted 60 day marker by chronologic age- use the corrected age.
Empiric antimicrobial treatment for necrotizing soft tissue infections (NSTIs) should include coverage of a wide range of pathogens including Staphylococcus spp, Streptococcus spp, anaerobic bacteria and gram negative bacteria. Treatment should also include an agent that suppresses toxin production by group A Streptococcus (GAS), with the Infectious Diseases Society of America (IDSA) guidelines recommending clindamycin plus penicillin for treatment of GAS causing necrotizing fasciitis and toxic shock syndrome. A typical empiric NSTI regimen would be vancomycin plus clindamycin plus piperacillin-tazobactam.
Linezolid is an appealing alternative to clindamycin and vancomycin, as it has anti-toxin effects via inhibition of exotoxin expression, potent in vitro activity against Streptococcus spp, activity against methicillin-resistant Staphylococcus aureus (MRSA), and potential for less adverse effects than clindamycin plus vancomycin. Several recent studies have looked at using linezolid in lieu of clindamycin plus vancomycin when treating NSTIs.
Published Studies:
Dorazio and colleagues published a retrospective single center study compared 62 matched pairs of patients who received linezolid vs. clindamycin plus vancomycin as part of their NSTI treatment.
Heil and colleagues published a retrospective single center cohort study examined patients who received either linezolid (n = 29) or clindamycin (n = 26) for treatment invasive soft tissue infection or necrotizing fasciitis with GAS isolated from blood and/or tissue.
Lehman and colleagues published a retrospective single center study compared patients who received linezolid (n = 21) versus clindamycin plus vancomycin (n = 28) in addition to gram-negative and anaerobic coverage for empiric treatment of NSTIs.
Bottom Line:
When added to an agent with good gram negative and anaerobic coverage (i.e. piperacillin-tazobactam), linezolid may be a more viable option for coverage of MRSA and GAS toxin production during empiric NSTI treatment when compared to clindamycin plus vancomycin. This is largely due to a more favorable side effect profile.
PEEP in the Ventilated COPD Patient?
Ultrasound is the first line diagnostic tool to evaluate younger patients who present to the ED with flank pain.
Most of the time on ultrasound, you will not see the actual kidney stone. More often, you will see associated signs such as hydronephrosis.
In a patient with hydronephrosis, the normally hyperechoic renal pelvis will become anechoic. With increased severity of the hydronephrosis, you can have complete distortion of the kidney.
You can tell the difference between hydronephrosis and a renal vein by placing color doppler over the image. Hydronephrosis will not have flow.
In this prospective study looking at geriatric patients with unknown head injury vs. known head injury, the unknown head injury group had an ICH 1.5%, neurosurgical intervention 0.3% and delayed ICH 0.1% when compared to known head injury (10.5%, 1.2% and 0.7% respectively). The authors concluded that the risk of ICH was high enough in uncertain head injury patients to warrant scanning.
Takeaway Message: In this study from England, the closure or downgrading of selected emergency departments had no observable impact on patient mortality.
Due to staffing shortages in the UK, the NHS has closed or reduced the capacity of some emergency departments thus strategically concentrating emergency services. The authors of this observational study sought to determine the impact on patient mortality from the closure of five emergency departments between 2007 and 2014. While transport time to an emergency department did increase by up to 25 minutes (median change - 9 minutes, range 0-25 minutes), no change in mortality was identified in the population studied.
The Bottom Line: Closure of selected emergency departments had no impact on population mortality in this UK study but the affected patients had other EDs in relatively close proximity to the ones that had closed.
Comment: This article's findings contradict those of a previously posted Pearl which noted a decrease in mortality when newly opened EDs reduced the volume of existing EDs (Woodworth L. Swamped: Emergency department crowding and patient mortality. Journal of Health Economics, 2020; 70: 102279). The reasons for this discrepancy are unclear but may be due to differences in the healthcare systems of the US and UK.
Background: For better or worse, the combination of “vanc-and-zosyn” has long been a go-to empiric regimen for the treatment of septic shock. Piperacillin-tazobactam is known to cause decreased creatinine secretion into the urine leading to an increased serum creatinine without any actual physiologic harm to the kidney, but the results of previous studies have led researchers to posit an increase in actual AKI with the vanc and zosyn combo. This concern has led to some physicians choosing cefepime for anti-pseudomonal gram-negative coverage instead, despite its known potential for neurotoxicity and cefepime-associated encephalopathy.
The ACORN trial: The recently published ACORN trial compared cefepime to piperacillin-tazobactam in adult patients presenting to the ED or medical ICU with sepsis or suspected serious infection. The primary outcome was a composite of highest stage of AKI or death at 14 days.
Results:
Bottom Line: Good antibiotic stewardship would probably decrease the frequency of vanc-and-zosyn administration, but concern for renal dysfunction alone shouldn’t guide the choice between cefepime or piperacillin-tazobactam, even in those with CKD, and even in those patients also receiving vancomycin.
Approximately half of all Medicare beneficiaries are now enrolled in Medicare Advantage plans. Why does this matter?
Intrigued? Learn more at https://www.nejm.org/doi/full/10.1056/NEJMhpr2302315 or https://www.kff.org/medicare/issue-brief/medicare-advantage-2024-spotlight-first-look/.
Many patients present to the emergency department for ankle swelling. On way to identify signs of intra-articular swelling is to use POCUS. To perform this, place the linear probe at the tibio-talar junction with the probe marker placed towards the patient’s head. An effusion is identified as anechoic fluid in-between the tibia and talus bone.
POCUS has been shown to improve first-pass success and overall success as compared to a landmark based approach for medium-sized joints. When performing an ankle arthrocentesis with POCUS, care should be taken to avoid blood vessels and tendons.
The question “Would I be surprised if the patient died within the next year” has been validated as a tool to predict patients with a limited life expectancy. This study looked at trauma team members’ ability to use this question to predict one year mortality. Trauma team members over estimated mortality in this study.
Reducing musculoskeletal injury and concussion risk in schoolboy rugby players with a pre-activity movement control exercise programme: a cluster randomised controlled trial
Intro: Musculoskeletal injuries and concussion are prominent reasons for time loss from sport for adolescent rugby players.
Injury patterns in rugby differ from other team sports,
-Greater frequency of concussion, upper body and contact-related injuries
Increased concussion risk is associated with lower neck strength, highlighting this characteristic as a potentially modifiable risk factor.
Enhancing neck muscle strength may prevent concussion by improving the dissipation of impact forces transmitted to the brain.
The aim of study was to determine the efficacy of a movement control exercise program in reducing injuries in youth rugby players.
Methods: In a cluster-randomized controlled trial, 40 independent schools (118 teams, 3188 players aged 14-18 years) were allocated to receive either the intervention or a reference program, both of which were to be delivered by school coaches.
The intervention comprised balance training, whole-body resistance training, plyometric training, and controlled rehearsal of landing and cutting maneuvers. This also included a neck strengthening component.
Time-loss (>24 hours) injuries arising from school rugby matches were recorded by coaches and medical staff.
Results: When trial arm comparisons were limited to teams who had completed three or more weekly program sessions on average, clear reductions in overall match injury incidence (RR=0.28) and concussion incidence (RR=0.41) were noted in the intervention group.
Conclusion:
Hot of the press from the Society of Critical Care Medicine (But most of us would know it already)
Settings: This is a prospective observational population-based study design with non-contemporaneous, nonrandomized clinical trial direct (unadjusted) head- to-head evaluations
Propensity score–matched comparisons of non-shockable cardiac arrest (NS-OHCA) patient survivor using conventional CPR (C-CPR) vs. C-CPR plus Automated Head/thorax up positioning-CPR (AHUP-CPR).
Participants: patients with non-traumatic, non-shockable out of hospital cardiac arrest (NS-OHCA).
Outcome measurement: primary outcome = survival, secondary outcome = survival with good neurologic outcome (Cerebral Performance Category score of 1–2 or modified Rankin Score less than or equal to 3).
Study Results:
• There was a total of 380 AHUP-CPR vs. 1852 C-CPR patients. After 1:1 matching, there were 353 AHUP-CPR patients and 353 C-CPR patients.
• In unadjusted analysis
o AHUP-CPR was associated with higher odds of survival (Odds ratio 2.46, 95% CI 1.55-3.92) and higher odds of survival with good neurologic function (Odds ratio 3.09 (95% CI 1.64-5.81)
• In matched groups
o AHUP-CPR was associated with higher odds of survival (Odds ratio 2.84, 95% CI 1.35-5.96) and higher odds of survival with good neurologic function [Odds ratio 3.87 (95% CI 11.27-11.78]
Discussion:
• There was no difference in rates of ROSC between groups. The authors argued that there was “neuroprotective effects” for the AHUP-CPR group.
• Although randomized controlled trials are usually required before clinical interventions are adopted, the aurthors argued that it would be difficult to randomize OHCA patients, and that the risk vs benefits may facilitate early adoption of this strategy.
• AHUP-CPR should be used first by well-trained clinicians to ensure its benefits.
Conclusion:
OHCA patients with NS presentations will have a much higher likelihood of surviving with good neurologic function when chest compressions are augmented by expedient application of the noninvasive tools to elevated head and thorax used in this study.
The routine use of ultrasound guidance has decreased CVC-related complications, especially in patients at risk for bleeding. To this day, however, platelet transfusion threshold guidelines range widely from 20,000 - 50,000 platelets per cubic millimeter, and also lack good-quality evidence.
This multicenter, randomized, controlled, noninferiority trial randomly assigned patients with severe thrombocytopenia (platelet count 10,000 to 50,000 per cubic millimeter) to receive either one unit of prophylactic platelet transfusion or no platelet transfusion before ultrasound-guided CVC placement.
Author's Conclusions: Withholding prophylactic platelet transfusion before CVC placement in patients with a platelet count of 10,000 to 50,000 per cubic millimeter did NOT meet the predefined margin for noninferiority and resulted in more CVC-related bleeding events than prophylactic platelet transfusion.
BUT…taking a closer look at this study reveals many nuanced points. Many of the study patients were heme/onc patients possibly having bleeding issues outside of low platelets, bleeding complications trended with subclavian and femoral locations as well as lower initial platelet counts. All this suggests that additional studies need to be done to move towards more specific evidenced-based guidelines.
To read more details on the study, click the referenced link.
From the Canadian Medical Protective Association looking at 5 years of closed medical legal cases. This fits with previous risk management data and should give us pause when treating these conditions.
This study was a retrospective review of restraint use at a level 1 trauma center in the Midwest.
It found the following were factors in a patient encounter associated with an increased risk of restraint usage:
This study found a decreased OR of restraint use with Black or Hispanic race, which was in contrast to other studies
This was a single center, retrospective study, so it was already limited in what it could tell us. In addition, they didn't see the reason for the restraints being ordered in the first place. Nonetheless, it does show that people in certain marginalized groups have a higher likelihood of ending up in restraints. Please think twice when ordering restraints in the ED, especially for behavioral reasons
